Breast Cancer - Diet, Exercise..risk, prevention & Treatment: Part IV

Breast Cancer: A Modern Epidemic

Preventive Concepts & Strategies for Optimal Health

By Dr. Michael Wald, Supervisor of Longevity Services at Integrated Medicine of Mt Kisco

495 E. Main Street, Mount Kisco, NY 10549 914-242-8844 /

www.intmedny.com  / www.blooddetective.com

The Essential Role of Nutrition and Exercise in Breast Cancer Treatment & Prevention

Practicing Healthy Lifestyle measures including diet and taking nutritional supplements has been shown in scientific studies to reduce one's risk of developing breast cancer and aids the successful treatment of breast cancer. Dietary and nutritional supplements, in my opinion, should be used by all people wishing to reduce risk and improve outcome, but should be carefully determined by a qualified clinical nutritionist.  

Below are some of my basic considerations in the area of diet and nutritional supplements. 

·      Diet

o   A few studies have evaluated the association between diet and mammographic breast density (MBD) and results are inconsistent. MBD, a well-recognized risk factor for breast cancer, has been proposed as a marker of cumulative exposure to hormones and growth factors. Diets with a high glycemic index (GI) or glycemic load (GL) may increase breast cancer risk, via an effect on the insulin-like growth factor axis. A positive association was suggested for increasing simple sugar and total carbohydrates intakes limited to the highest quintiles.

o   The consumption of probiotics (healthy bacteria) and fermented products (i.e., lactobacillus plantarum) containing lactic acid bacteria was associated to reduce breast cancer risk.

o   It was observed that a balance of fatty acids similar to those of traditional Mediterranean diet, the consumption of fruits and vegetables, dietary fiber intake, vitamin supplementation are, along with the intake of probiotic products, the most extensively studied by the negative association to breast cancer risk. Omega 3 fatty acids from fish is probably the best source – as long as it is free of heavy metals such as mercury and aluminum (found in fish of all types).

o   Green/yellow and light colored vegetables were associated with a reduced risk of breast cancer. I favor the addition of concentrates of fruits and vegetables that are essentially dehydrated products that can easily be taken as a delicious drink in addition to a balanced diet. See www.blooddetective.com and search Green Detox, Reds Protect, Brain Energy Blast and Longevity Complete - these products have not been studied directly for breast cancer prevention or treatment, but many of their ingredients have). 

·      Exercise

o   Avoiding obesity: Scientific evidences have suggested that obesity has associated with increased risk for a plenty of different types of cancer. The evidences are the most consistent for endometrial cancer, breast cancer between the postmenopausal women, and renal cell cancer.

o   Exercise during breast cancer treatment is perceived to enhance the patients' wellness on several dimensions and in particular psychological wellness. Exercise might support the patients' efforts to restore their sense of wellness and enhance their level of daily life functioning.  Exercise improves liver and intestinal detoxification of cancer-promoting estrogen such as estradiole.

o   Physical activity, may be able to counteract genetic susceptibility to breast cancer.  Exercise has shown to be a protective factor for breast cancer, increases the level of DNA methylation. Fibroblast growth factor receptor 2 (FGFR2), a confirmed breast cancer susceptibility gene, is predisposed to be methylated. Therefore, DNA methylation related genes, such as methylenetetrahydrofolate reductase (MTHFR) or active folic acid.

o   Motivate breast cancer patients toward engaging in a healthy lifestyle early after diagnosis and adhering to PA programs, which should be included in their clinical management.  Exercise has shown to improve quality of life for those pre and post breast cancer.

o   Pre-, concurrent and post-chemo nutrition to prevent increased risk of various cancers resulting directly from the immunosuppressive long-term effects of chemotherapy. Also to offset the risk, depending upon the form(s) of chemotherapy, of “chemo-brain, peripheral neuropathies, gastrointestinal and other health issues.

 

Nutritional supplements

o   Multivitamin and breast cancer

§  Although this study is a case-control study in which the risk of BC could not be assessed, results suggest that vitamin supplementation could be an independent protective factor for BC. Calcium intake appears to affect DRC in a positive way, because it was associated with a high DRC (DNA repair capacity) level, which in turn is associated with low odds for BC.  (Postmenopausal women with invasive breast cancer using MVM had lower breast cancer mortality than non-users. The results suggest a possible role for daily MVM use in attenuating breast cancer mortality in women with invasive breast cancer but the findings require confirmation. (Breast Cancer Res Treat. 2013 Oct;141(3):495-505. doi: 10.1007/s10549-013-2712-x. Epub 2013 Oct 9. Multivitamin and mineral use and breast cancer mortality in older women with invasive breast cancer in the women's health initiative.)

o   Studies show there is an inverse relationship between the low serum levels of vitamin D and the breast cancer risk and mortality

§  Therefore increasing serum levels will reduce ones risk for development.

o   Antioxidants: The resulting oxidative stress might also play a relevant role in several stages of the carcinogenic process.

Vitamin D3: A meta-analysis, a comprehensive analysis of well-designed scientific studies, provides evidence of a significantly inverse association between serum vitamin D3 levels (as 25(OH)D) and breast cancer risk.  Some studies have also shown that vitamin D3 supplementation in patients with non-metastatic (did not spread to other parts of the body) HER2+ breast cancer is associated with improved DFS (disease-free survival).

Vitamin E and Vitamin C: Severe α-tocopherol deficiency could increase breast cancer risk. The association between plasma vitamin C and breast cancer was only significant in case-control studies.  Intravenous vitamin C and vitamin K have been shown to be a safe and effective adjunctive treatment for breast and other forms of cancer.

Melatonin: Due to anti-estrogenic properties, melatonin is considered to exhibit a protective role against the development of breast cancer (BC).  An inverse association between BC risk and the highest levels of urinary aMT6s

See below for various nutritional based treatments shown to reduce breast cancer risk.

Dehydrated Fruits and Vegetables: Fruits and vegetables contain hundreds of healthful natural compounds and dozens and dozens of anti-cancer compounds – both to help prevent and treat various types of cancers including breast cancer. Many of the plant or phyto-nutrients found in plants are contained with my formulations called –

1.     Green’s Detox - http://www.blooddetective.com/green-detox

2.     Red’s Protect - http://www.blooddetective.com/reds-protect

3.     Longevity Complete  - http://www.blooddetective.com/longevity-complete

4.     Brain Energy Blast - http://www.blooddetective.com/brain-energy-blast

For more about the above nutritional supplements go to: www.blooddetect.com

Biochemical Uniqueness – How and why to get tested for your unique nutritional imbalances 

The number and variety of nutritional products including vitamins, minerals herbs and other nutritional compounds scientifically studied for both prevention and treatment of breast cancer is far beyond the scope of these blogs.  It’s important to keep in mind that a careful health and medical history, nutritional questionnaires, detailed laboratory and functional tests are performed. Here are a few examples of the most important tests that I use to determine the right type of food plan and nutritional supplements to provide my patients – whether they wish to prevent and treat breast cancer.

1.     Complete Blood Count and Chemistry Profile: These lab panels include red and white blood cells, electrolytes and other basic tests, but I further evaluate them by performing a nutritional interpretation of each of my patients results by comparing them to healthy individuals and not merely “average” people – this is what the regular tests ranges used by all doctors (known as “clinical” ranges) compare people to. Bottom line, if you want average health then use only “clinical ranges”; if you want a shot at optimal health then also use “functional ranges”.

2.     Homocysteine and Methylmalonic acid tests: These tests, when combined let me know if my patients are receiving the appropriate amounts of, and USING,  vitamin B6, folic acid and vitamin 12 correctly. Eating foods and taking nutritional supplements with these or other nutritional compounds does not always mean that one is absorbing or using their nutrients properly. Active folic acid, B12 and B6 is not the same as what most foods or even vitamin supplements contain. It is essential, especially in the case of folic acid, to take only the active form; it’s important for reducing cancer risk in the first place and plays a potentially important role in cancer treatment as well.  

3.     Vitamin D3 (25-OH) and vitamin D3 (1, 25-OH): The higher normal one’s level of vitamin D the lower one’s overall morbidity and mortality from any cause of death.

4.     Vitamin C serum levels: The higher the blood levels the better for breast cancer treatment.

5.     CRP-cardio – A non-specific inflammatory marker with important nutritional considerations.  CRP in the “cardio” form of the test, is thought to be the single most predictive blood test that predicts morbidity and mortality (along with other tests).  Different type of inflammatory markers reveal other potential health issues and nutrient needs and include: ESR, fibrinogen, ferritin and tumor necrosis factor alpha and others.

6.     Antibody Profile – A panel that measures a variety of antibodies that identify potential nutritional targets.

7.     Comprehensive Immune Testing: We have many immune systems. The most important that should be measured, and can reveal many important nutritional clues, include: cell-mediated immune tests, complement immune testing and Humoral Immune Tests.

8.     Body Composition Tests – A simple test that measures one’s percentage of muscle, water and fat and metabolic rate – all important predictive markers of disease risk and survivability.

9.     Sonogram Bone Density: Loss of bone density may be associated with calcium breast cysts (highly predictive of breast cancer development), osteoarthritis and hardening of the arteries (atherosclerosis).

 

This is my short list – other evaluations are based on the unique health history, stage of disease, health goals and other factors.

 

Environmental Chemicals & Breast Cancer That Might Influence Breast Cancer Development & Recovery

1.     Most DNA mutations related to breast cancer occur in single breast cells during a woman's life rather than having been inherited. 

2.     85,000 synthetic chemicals on the market today including, but not limited to, preservatives, lipstick, sunscreens, and deodorants, the flame retardants to our sofas, plasticizers in our water bottles, pesticides on our fruits and vegetables, and GMOs.

3.     70% of those with breast cancer have no known risk factors like late menopause, children late in life or family history or genes.

4.     Non-industrialized countries have lower rates of breast cancer compared with industrialized countries; those who move to countries with lower rates experienced lower rates.  Estrogen is linked to development of breast cancer.  Xenoestrogens act like estrogens (weed killers and pesticides, plastic additives or by-products, ingredients in spray paints and paint removers, and polyvinyl chloride (PVC), used in food manufacture and food packaging, medical products, cars, toys, credit cards, appliances, and rainwear.

5.     The burden of environmental chemicals has been underestimated (http://www.bcaction.org/our-take-on-breast-cancer/environment/)

What are some simple lifestyle considerations to reduce ones risk include?

·      No smoking and avoidance of second hand smoke and air pollution.

·      Eliminate saturated and trans fats.

·      No alcohol: Alcohol consumption is associated with an increased risk of breast cancer, increasing linearly even with a moderate consumption and irrespectively of the type of alcoholic beverage.

·      Avoiding Estrogens are known that they may produce breast cancer by actions on estrogen receptors and also as chemical carcinogens, as a consequence of their oxidation leading to reactive metabolites.

·      Avoiding excessive radiation and taking nutritional precautions are associated with a reduction in risks. 

·      Type 2 diabetes mellitus is an independent risk factor for cancer such as pancreatic, liver, colorectal and breast cancer. In addition, diabetes decreases the risk of prostate cancer.  Further stressing the importance of diet, exercise, and proper supplementation.

·      Infections (viruses) and breast cancer

o   Human Papilloma virus HPV- High-risk human papillomaviruses (HPV) are the causative agent of several cancers especially breast cancer.

o   Human cytomegalovirus (HCMV), a common herpes virus, has been reported to be a risk factor for many diseases, including malignant diseases such as glioma, neuroblastoma, and breast cancer.

o   Evidence is accumulating that one or more beta-retrovirus is associated with human breast cancer.

 

Q-What treatments for breast cancer that are in studies now do you see as the new movement for treatment?

·      Intravenous vitamin C (http://www.ncbi.nlm.nih.gov/pubmed/23916956)

o   Plasma antioxidants are supposed to be directly related to breast cancer risk.

o   Severe α-tocopherol deficiency could increase breast cancer risk. 

·      Intravenous infusions of modest doses of DHA may have potential for optimizing the intracellular ascorbate content of cancers, potentially rendering them less aggressive. 

·      Intravenous hydrogen peroxide

o   Intravenous infusion of hydrogen peroxide or h2o2 delivers a positive metabolic effect and may oxidize respective physiological substances by promoting healthful tissue growth and increments cellular oxygen tension, which hinders the growth or development of tumors.

·      Intravenous sodium bicarbonate: True pH “balancing, True Detoxification

o   Oral sodium bicarbonate and intravenous DHA may have the potential to blunt the aggressiveness of certain cancers in which suboptimal intracellular ascorbate levels contribute to elevated HIF-1 activity.

·      Hyperbaric Ambient Air

o   Hyperbaric Oxygen significantly improved the radiation response of R1H tumors. HBO appeared to be more effective than normobaric carbogen, both with regard to tumor oxygenation and response to irradiation.

·      Bioimpedance therapy (BIS)

o   Bioimpedence spectroscopy has shown to be able to detect early onset lymphedema.

o   BIS has significant clinical utility as it can be used to monitor patients with early breast cancer related risk.

o   More systematic surveillance for earlier detection and the potential benefits of physical activity to prevent lymphedema and mitigate symptoms and reduce risk factors.

Healthy blood ranges

·      Integrated work ups

o   One should have regular mammograms in order to monitor activity within the body

o   Vitamin levels such as vitamin A, D, and C should be regulated and this has shown to decrease ones risk.

o   Regular blood work can monitor hormones levels especially those associated with breast cancer risk.

o   Proper checking of the lymphatics for adequate removal of toxins is necessary

NEXT BLOG: Breast Cancer - The Toxins, Treatments & Disease Connection

None of the statements herein have been approved by the FDA (Food & Drug Administration) nor does this information substitute for sound medical or nutritional health advice.

Contact us for a free 15-minute consultation by calling: 914-242-8844.