Here is my response to a question posed to me. Is Maca effective for treating PDD? If not, what are the best natural treatments? Maca may help, but there are several other natural compounds that make even more sense than Maca. An enzyme known as catecol-o--methyltransferase has been shown to be somewhat dysfunctional in sufferers of PDD. This enzyme is folic acid dependent. A special form of folic acid known as L-5-methyltetrahydrofolic acid is the best form and should be taken as 1-2 mg (milligrams, not micrograms) per day. Omega 3 fats in the form of krill oil (and in a triglyceride form) is best absorbed. Magnesium in the form of a chelate is best for most people at a dose of 100-200 mg per day.
Problems with serotonin and or serotonin uptake at receptor sites is also an issue. Nutrients to help with this include the active folate described above, methylated B12 (1000 mcg per day), active vitamin B6 (in the pyridoxyl-5-phosphate form), melatonin (3-9 mg per day taken only at night 1 hr or less before bed), active tryptophane and a multivitamin. The rest of the nutrition best for PDD should be determined on the specific nutritional and other laboratory (blood) abnormalities found upon detailed blood testing. Unfortunately, most mainstream doctors are completely oblivious to these and other nutritional approaches to PDD or how or which tests to run on blood testing. Cleaning up the diet by eliminating saturated and trans fats, refined and processed carbohydrates, eating organically when possible, exercising regularly, eliminating red meats or eating just free-range, organically fed meat, eating free-range fish rich in omega 3 fatty acids, not drinking alcohol and drinking lots of water (until the urine is just a little yellow) are the best overall strategies.
These nutrients can be purchased at: www.blooddetective.com.